Genome-Wide Analysis of Allele-Specific Expression Patterns in Seventeen Tissues of Korean Cattle (Hanwoo).
Kyu-Sang LimSun-Sik ChangBong-Hwan ChoiSeung-Hwan LeeKyung Tai LeeHan-Ha ChaiJong-Eun ParkWoncheoul ParkDajeong LimPublished in: Animals : an open access journal from MDPI (2019)
The functional hemizygosity could be caused by the MAE of a given gene and it can be one of the sources to affect the phenotypic variation in cattle. We aimed to identify MAE genes across the transcriptome in Korean cattle (Hanwoo). For three Hanwoo family trios, the transcriptome data of 17 tissues were generated in three offspring. Sixty-two MAE genes had a monoallelic expression in at least one tissue. Comparing genotypes among each family trio, the preferred alleles of 18 genes were identified (maternal expression, n = 9; paternal expression, n = 9). The MAE genes are involved in gene regulation, metabolic processes, and immune responses, and in particular, six genes encode transcription factors (FOXD2, FOXM1, HTATSF1, SCRT1, NKX6-2, and UBN1) with tissue-specific expression. In this study, we report genome-wide MAE genes in seventeen tissues of adult cattle. These results could help to elucidate epigenetic effects on phenotypic variation in Hanwoo.
Keyphrases
- genome wide
- poor prognosis
- genome wide analysis
- dna methylation
- genome wide identification
- gene expression
- immune response
- bioinformatics analysis
- copy number
- transcription factor
- binding protein
- long non coding rna
- physical activity
- machine learning
- type diabetes
- insulin resistance
- body mass index
- metabolic syndrome
- pregnant women
- electronic health record
- adipose tissue
- big data
- artificial intelligence
- data analysis
- dna binding
- childhood cancer