Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines.
Ruyi ZhangShanshan LiKelly SchippersBoaz EimersJiahui NiuBastian V H HornungMirjam C G N van den HoutWilfred F J Van IJckenMaikel Petrus PeppelenboschRon SmitsPublished in: PloS one (2024)
Our study provides insights into the effects of repairing AXIN1 mutations on β-catenin signaling, cell viability, and colony formation in HCC cell lines. However, further investigations are necessary to understand the complex mechanisms underlying HCC development associated with AXIN1 mutations.
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