Maternal folic acid supplementation for the prevention of preeclampsia: A systematic review and meta-analysis.

Rhodi E Bulloch Amy Luisa Lovell Vanessa M B Jordan Lesley M E McCowan John M D Thompson Clare Rosemary Wall

Published in: Paediatric and perinatal epidemiology (2018)

Low level evidence is available for a modest association between maternal folic acid supplementation and reduction in preeclampsia risk. Future studies should differentiate between early and late onset and mild vs severe preeclampsia, and should control for relevant confounders including the presence of multivitamin supplements. The protocol for this systematic review was prospectively registered with PROSPERO (CRD42015029310).

Keyphrases

early onset
late onset
systematic review
pregnancy outcomes
birth weight
meta analyses
randomized controlled trial
pregnant women
current status
body mass index
case control
gestational age
physical activity
drug induced