Changes in treatment and mortality in men with locally advanced prostate cancer between 2000 and 2016: a nationwide, population-based study in Sweden.
Andri Wilberg OrrasonMarcus WesterbergHans GarmoIngela Franck LissbrantDavid L RobinsonPär StattinPublished in: BJU international (2020)
The threefold increase in use of radical treatment was accompanied by a modest decrease in PCa mortality in all men with newly diagnosed locally advanced PCa. For men aged 65-74 years, there was a 50% decrease in the relative risk of PCa death. This indicates that the benefits previously observed in randomised trials can also be achieved in a real-life setting.
Keyphrases
- locally advanced
- prostate cancer
- squamous cell carcinoma
- newly diagnosed
- rectal cancer
- neoadjuvant chemotherapy
- cardiovascular events
- clinical trial
- middle aged
- radiation therapy
- randomized controlled trial
- open label
- radical prostatectomy
- cardiovascular disease
- type diabetes
- combination therapy
- study protocol
- phase ii study
- placebo controlled