Does liraglutide alleviates inflammation in brain-dead donors? A randomized clinical trial.
Geisiane CustódioAndrew Maykon MassuttiMauro Rafael da IgrejaNatália Emerim LemosDaisy CrispimFernanda VisioliVictor de Mello PalmaCristiane Bauermann LeitãoLilian Rodrigues HenriquePublished in: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2023)
Liraglutide administration reduced IL-6 and prevented the increase of IL-10 plasma levels in brain-dead donors, without affecting the expression of genes and proteins related to inflammation, apoptosis, endoplasmic reticulum stress, or oxidative stress.
Keyphrases
- oxidative stress
- endoplasmic reticulum stress
- induced apoptosis
- resting state
- white matter
- diabetic rats
- ischemia reperfusion injury
- dna damage
- poor prognosis
- functional connectivity
- cerebral ischemia
- kidney transplantation
- mouse model
- signaling pathway
- binding protein
- cell proliferation
- multiple sclerosis
- heat shock
- brain injury
- cell death
- dna methylation
- subarachnoid hemorrhage
- heat stress