Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes.
Heiko SommerIlan MarekPublished in: Chemical science (2018)
A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described P-stereogenic xantphos derivative as ligand.
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