Antimicrobial Pharmacokinetics and Dosing in Critically Ill Adults Receiving Prolonged Intermittent Renal Replacement Therapy: A Systematic Review.

This systematic review updates and addresses issues of quality in previous systematic reviews on this topic. Despite an overall low quality of evidence, strong recommendations were able to be made for almost half of the identified antimicrobials. Knowledge gaps persist for many antimicrobials and higher quality studies (i.e., population PK studies with assessment of PD target attainment) are needed to address these gaps.