Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells.

Hong-Mou ShihSzu-Yu PanChih-Jen WuYu-Hsiang ChouChun-Yuan ChenFan-Chi ChangYi-Ting ChenWen-Chih ChiangHsing-Chen TsaiYung-Ming ChenShuei-Liong Lin

Published in: Journal of biomedical science (2021)

C3H10T1/2 cells possessed the property of HIF2α-dependent Epo expression in REP pericytes. TGF-β1 induced not only the transition to myofibroblasts but also a repressive effect on Epas1-Epo axis in C3H10T1/2 cells. The repressive effect of TGF-β1 on Epas1-Epo axis was confirmed in REP pericytes in vivo. Inhibition of TGF-β1-ALK5 signaling might provide a novel treatment to rescue EPO expression in REP pericytes of injured kidney.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
poor prognosis
induced apoptosis
binding protein
cell cycle arrest
recombinant human
signaling pathway
high glucose
cell death
oxidative stress
cell proliferation
epidermal growth factor receptor
pi k akt