Cytotoxic and Antibacterial Cervinomycins B1-4 from a Streptomyces Species.
Xiaowen HuXinxin HuXiaomin HuShufen LiLinLi LiLi-Yan YuHongyu LiuXuefu YouZhen WangLi LiBeibei YangBingya JiangLinzhuan WuPublished in: Journal of natural products (2019)
AntiSMASH analysis of genome DNA of Streptomyces CPCC 204980, a soil isolate with potent antibacterial activity, revealed a gene cluster for polycyclic xanthones. A subsequent chemical study confirmed that the microorganism produced polycyclic xanthone cervinomycin A2 (1) and the new congeners cervinomycins B1-4 (2-5). The structures of 1-5 were determined by comprehensive analyses of MS and NMR data, which indicated that 2-5 featured a common dihydro-D ring in the polycyclic xanthone core moiety of their molecules. 2-5 are toxic to human cancer cells and active against Gram-positive bacteria.
Keyphrases
- high resolution
- endothelial cells
- genome wide
- silver nanoparticles
- mass spectrometry
- multiple sclerosis
- electronic health record
- circulating tumor
- copy number
- ms ms
- gram negative
- cell free
- single cell
- induced pluripotent stem cells
- machine learning
- pluripotent stem cells
- data analysis
- multidrug resistant
- artificial intelligence
- wound healing