Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis.

Giuliana Guggino Daniele MauroAroldo RizzoRiccardo AlessandroStefania RaimondoAnne-Sophie BergotM Arifur RahmanJonathan J EllisSimon MillingRik Ju Lories Dirk Elewaut Matthew A Brown Ranjeny Thomas Francesco Ciccia

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Inflammasome activation occurs in rodent models of AS and in AS patients, is associated with dysbiosis, and is involved in triggering ileitis in SKG mice. Inflammasomes drive type III cytokine production with an IL-1β-dependent mechanism in AS patients.

Keyphrases

end stage renal disease
ankylosing spondylitis
ejection fraction
newly diagnosed
chronic kidney disease
type iii
prognostic factors
type diabetes
peritoneal dialysis
high fat diet induced