Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis.
Giuliana GugginoDaniele MauroAroldo RizzoRiccardo AlessandroStefania RaimondoAnne-Sophie BergotM Arifur RahmanJonathan J EllisSimon MillingRik Ju LoriesDirk ElewautMatthew A BrownRanjeny ThomasFrancesco CicciaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Inflammasome activation occurs in rodent models of AS and in AS patients, is associated with dysbiosis, and is involved in triggering ileitis in SKG mice. Inflammasomes drive type III cytokine production with an IL-1β-dependent mechanism in AS patients.