Upper respiratory symptoms worsen over time and relate to clinical phenotype in chronic obstructive pulmonary disease.

Arturo HuertaGavin C DonaldsonRicha SinghAlex J MackayJames P AllinsonSimon E BrillBeverly KowlessarAntoni TorresJadwiga A Wedzicha

Published in: Annals of the American Thoracic Society (2016)

Upper airway symptoms increase over time in patients with COPD and are related to the frequent exacerbation phenotype. These longitudinal changes may be due to increasing airway inflammation or to progression of COPD.

Keyphrases

chronic obstructive pulmonary disease
lung function
cross sectional
air pollution
physical activity
depressive symptoms
drug induced