A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice.
Madeline Rose KeleherRabab ZaidiLauren HicksShyam ShahXiaoyun XingDaofeng LiTing WangJames M CheverudPublished in: BMC genomics (2018)
Discovering the gene expression and methylation changes associated with a high-fat diet can help to identify new targets for epigenetic therapies and inform about the physiological changes in obesity. Here, we identified numerous genes with altered expression and methylation that are promising candidates for further study.
Keyphrases
- high fat diet
- dna methylation
- genome wide
- gene expression
- insulin resistance
- high fat diet induced
- adipose tissue
- copy number
- metabolic syndrome
- type diabetes
- skeletal muscle
- poor prognosis
- weight loss
- binding protein
- transcription factor
- long non coding rna
- body mass index
- genome wide identification
- bioinformatics analysis