A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus.

Eleni Christodoulou-VafeiadouChristina GekaLida IliopoulouLydia NtariMaria C DenisNiki KaragianniGeorge Kollias

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

We have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of hIL-23A. This new model has a normal lifespan and integrates several characteristics of the human disease's complexity and chronicity making it an attractive preclinical tool for studying IL23-dependent pathogenic mechanisms and assessing the efficacy of anti-hIL23A or modeled disease-related therapeutics.

Keyphrases

systemic lupus erythematosus
mouse model
endothelial cells
induced pluripotent stem cells
disease activity
pluripotent stem cells
small molecule
stem cells
rheumatoid arthritis
drosophila melanogaster