Vasoactive intestinal peptide shapes first-trimester placenta trophoblast, vascular, and immune cell cooperation.
Daniel Esteban PapariniRuhul H ChoudhuryDaiana M VotaMagdalena Karolczak-BayattiSarah Finn-SellEsteban N GrassoVanesa C HaukRosanna RamhorstClaudia Pérez LeirósJohn D AplinPublished in: British journal of pharmacology (2019)
The results suggest that VIP assists the progress of EVT invasion and vessel remodelling in first-trimester placental bed in an immunologically "silent" milieu. The effects of VIP in the present ex vivo human placental model endorse its potential as a therapeutic candidate for deep placentation disorders.