Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury.

Sho HasegawaTsuyoshi InoueYasuna NakamuraDaichi FukayaRie UniChia-Hsien WuRie FujiiWachirasek PeerapanyasutAkashi TaguchiTakahide KohroShintaro YamadaMikako KatagiriToshiyuki KoSeitaro NomuraAtsuko Nakanishi OzekiEtsuo A SusakiHiroki R UedaNobuyoshi AkimitsuYouichiro WadaIssei KomuroMasaomi NangakuReiko Inagi

Published in: Journal of the American Society of Nephrology : JASN (2021)

The activation of Adrb2 signaling in macrophages induces anti-inflammatory phenotypic alterations partially via the induction of Tim3 expression, which blocks LPS-induced systemic inflammation and protects against renal IRI.

Keyphrases

lps induced
ischemia reperfusion injury
inflammatory response
anti inflammatory
poor prognosis
oxidative stress