BF 3 ·Et 2 O-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides.

Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF 3 ·Et 2 O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process.