Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1.
Ren Xiang TanGuan-Cheng DaiBei-Bei ZhouYong ChenRen-Xiang TanPublished in: Journal of Asian natural products research (2021)
Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin (1), 6-methoxy-2-ethoxycarbonyl-endocrocin (2) and pannorin C (3), along with sixteen known compounds (4-19) were isolated from a plant endophytic fungus Aspergillus cristatus 2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound 3 showed weak antibacterial activity against Staphylococcus aureus (MIC 20 μg/ml). Compounds 14 and 15 showed effective cytotoxicity on human melanoma A375 cells (IC50 4.13 μM for 14, 3.39 μM for 15).
Keyphrases
- data analysis
- ms ms
- staphylococcus aureus
- induced apoptosis
- cell wall
- high resolution
- endothelial cells
- cell cycle arrest
- mass spectrometry
- magnetic resonance
- multiple sclerosis
- structure activity relationship
- induced pluripotent stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- solid state
- escherichia coli
- methicillin resistant staphylococcus aureus
- cell proliferation
- skin cancer