Composite endpoint for ALS clinical trials based on patient preference: Patient-Ranked Order of Function (PROOF).

Ruben P A van EijkL H van den BergYing Lu

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

The PROOF endpoint provides a balanced patient-focused analysis of the improvement in function and may help to refine the risk-benefit assessment of new treatments for ALS.

Keyphrases

case report
clinical trial
amyotrophic lateral sclerosis
randomized controlled trial
open label
study protocol