Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources.
Andrea SchmidtsLeah C MarshAmbike A SrivastavaAmanda A BouffardAngela C BoroughsIrene ScarfoRebecca C LarsonFelipe BedoyaBryan D ChoiMatthew J FrigaultStefanie R BaileyMark B LeickSonika VatsaMichael C KannMichelle S PrewBenjamin P KleinstiverJ Keith JoungMarcela V MausPublished in: Journal for immunotherapy of cancer (2021)
Our aAPC-ΔLDLR represent an attractive approach for manufacturing of lentivirally transduced T cells that may be simpler and more cost efficient than currently available methods.