Benjamin P Kleinstiver (Benjamin Kleinstiver)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 49

Top Topics

Top Venues

bioRxiv : the preprint server for biology

Nature biotechnology

Nature communications

Nature microbiology

This page only lists publications with an associated author ORCID identifier.

Publications

Zachariah L McLean, Dadi Gao, Kevin Correia, Jennie C L Roy, Shota Shibata, Iris N Farnum, Zoe Valdepenas-Mellor, Marina Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P Kleinstiver, Jong-Min Lee, Marcy E MacDonald, Vanessa C Wheeler, Ricardo Mouro Pinto, James F Gusella
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat. Nature communications 15 (1) (2024)
Joana Ferreira da Silva, Connor J Tou, Emily M King, Madeline L Eller, David Rufino-Ramos, Linyuan Ma, Christopher R Cromwell, Jasna Metovic, Friederike M C Benning, Luke H Chao, Florian S Eichler, Benjamin P Kleinstiver
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nature biotechnology (2024)
Joana Ferreira da Silva, Connor J Tou, Emily M King, Madeline L Eller, David Rufino-Ramos, Linyuan Ma, Christopher R Cromwell, Jasna Metovic, Friederike M C Benning, Luke H Chao, Florian S Eichler, Benjamin P Kleinstiver
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nature biotechnology (2024)
Joana Ferreira da Silva, Connor J Tou, Emily M King, Madeline L Eller, David Rufino-Ramos, Linyuan Ma, Christopher R Cromwell, Jasna Metovic, Friederike M C Benning, Luke H Chao, Florian S Eichler, Benjamin P Kleinstiver
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nature biotechnology (2024)
Zachariah L McLean, Dadi Gao, Kevin Correia, Jennie C L Roy, Shota Shibata, Iris N Farnum, Zoe Valdepenas-Mellor, Marina Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P Kleinstiver, Jong-Min Lee, Marcy E MacDonald, Vanessa C Wheeler, Ricardo Mouro Pinto, James F Gusella
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat. Nature communications 15 (1) (2024)
Zachariah L McLean, Dadi Gao, Kevin Correia, Jennie C L Roy, Shota Shibata, Iris N Farnum, Zoe Valdepenas-Mellor, Marina Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P Kleinstiver, Jong-Min Lee, Marcy E MacDonald, Vanessa C Wheeler, Ricardo Mouro Pinto, James F Gusella
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat. Nature communications 15 (1) (2024)
Zachariah L McLean, Dadi Gao, Kevin Correia, Jennie C L Roy, Shota Shibata, Iris N Farnum, Zoe Valdepenas-Mellor, Marina Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P Kleinstiver, Jong-Min Lee, Marcy E MacDonald, Vanessa C Wheeler, Ricardo Mouro Pinto, James F Gusella
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat. Nature communications 15 (1) (2024)
Joana Ferreira da Silva, Connor J Tou, Emily M King, Madeline L Eller, David Rufino-Ramos, Linyuan Ma, Christopher R Cromwell, Jasna Metovic, Friederike M C Benning, Luke H Chao, Florian S Eichler, Benjamin P Kleinstiver
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nature biotechnology (2024)
Joana Ferreira da Silva, Connor J Tou, Emily M King, Madeline L Eller, David Rufino-Ramos, Linyuan Ma, Christopher R Cromwell, Jasna Metovic, Friederike M C Benning, Luke H Chao, Florian S Eichler, Benjamin P Kleinstiver
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nature biotechnology (2024)
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morín, Almudena Fernández, Logan T Hille, Rachel A Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim F Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J M Mojica, Benjamin P Kleinstiver, Miguel Angel Moreno-Pelayo, Lluís Montoliu, Raul Perez-Jimenez
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins. Nature microbiology 8 (1) (2023)
Christiano R R Alves, Leillani L Ha, Rebecca A Yaworski, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv : the preprint server for biology (2023)
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M Loupe, Vanessa C Wheeler, Hannah E Stutzman, Benjamin P Kleinstiver, Jong-Min Lee
Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease. bioRxiv : the preprint server for biology (2023)
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morín, Almudena Fernández, Logan T Hille, Rachel A Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim F Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J M Mojica, Benjamin P Kleinstiver, Miguel Angel Moreno-Pelayo, Lluís Montoliu, Raul Perez-Jimenez
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins. Nature microbiology (2023)
Christiano R R Alves, Leillani L Ha, Rebecca Yaworski, Emma R Sutton, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy. Nature biomedical engineering (2023)
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N Whittaker, John A Zuris, David B Thompson, Arun Prabhu Rameshbabu, Yi-Lai Shu, Xue Gao, Johnny H Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P Kleinstiver, David R Liu, Zheng-Yi Chen
Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo. Nature communications 14 (1) (2023)
Lin Zhao, Sabrina R T Koseki, Rachel A Silverstein, Nadia Amrani, Christina Peng, Christian Kramme, Natasha Savic, Martin Pacesa, Tomas C Rodriguez, Teodora Stan, Emma Tysinger, Lauren Hong, Vivian Yudistyra, Manvitha R Ponnapati, Joseph M Jacobson, George M Church, Noah Jakimo, Ray Truant, Martin Jinek, Benjamin P Kleinstiver, Erik J Sontheimer, Pranam Chatterjee
PAM-flexible genome editing with an engineered chimeric Cas9. Nature communications 14 (1) (2023)
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morín, Almudena Fernández, Logan T Hille, Rachel A Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim F Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J M Mojica, Benjamin P Kleinstiver, Miguel Angel Moreno-Pelayo, Lluís Montoliu, Raul Perez-Jimenez
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins. Nature microbiology 8 (1) (2023)
Michelle Y Fry, Paula P Navarro, Xingping Qin, Zintis Inde, Virly Y Ananda, Camila Makhlouta Lugo, Pusparanee Hakim, Bridget E Luce, Yifan Ge, Julie L McDonald, Ilzat Ali, Leillani L Ha, Benjamin P Kleinstiver, David C Chan, Kristopher A Sarosiek, Luke H Chao
In situ architecture of Opa1-dependent mitochondrial cristae remodeling. bioRxiv : the preprint server for biology (2023)
Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P Kleinstiver, Guillaume Lettre
Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells. PLoS genetics 19 (3) (2023)
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morín, Almudena Fernández, Logan T Hille, Rachel A Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim F Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J M Mojica, Benjamin P Kleinstiver, Miguel Angel Moreno-Pelayo, Lluís Montoliu, Raul Perez-Jimenez
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins. Nature microbiology 8 (1) (2023)
Young-Hoon Kim, Nahye Kim, Ikenna Okafor, Sungchul Choi, Seonwoo Min, Joonsun Lee, Seung-Min Bae, Keunwoo Choi, Janice Choi, Vinayak Harihar, Youngho Kim, Jin-Soo Kim, Benjamin P Kleinstiver, Jungjoon K Lee, Taekjip Ha, Hyongbum Henry Kim
Sniper2L is a high-fidelity Cas9 variant with high activity. Nature chemical biology (2023)
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M Loupe, Vanessa C Wheeler, Hannah E Stutzman, Benjamin P Kleinstiver, Jong-Min Lee
Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease. bioRxiv : the preprint server for biology (2023)
Connor J Tou, Benno Orr, Benjamin P Kleinstiver
Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases. Nature biotechnology (2023)
Sabrina Koseki, Lauren Hong, Vivian Yudistyra, Teodora Stan, Emma Tysinger, Rachel Silverstein, Christian Kramme, Nadia Amrani, Natasha Savic, Martin Pacesa, Tomas C Rodriguez, Manvitha Ponnapati, Joseph Jacobson, George Church, Ray Truant, Martin Jinek, Benjamin P Kleinstiver, Erik J Sontheimer, Pranam Chatterjee
PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Research square (2023)
Michelle Y Fry, Paula P Navarro, Xingping Qin, Zintis Inde, Virly Y Ananda, Camila Makhlouta Lugo, Pusparanee Hakim, Bridget E Luce, Yifan Ge, Julie L McDonald, Ilzat Ali, Leillani L Ha, Benjamin P Kleinstiver, David C Chan, Kristopher A Sarosiek, Luke H Chao
In situ architecture of Opa1-dependent mitochondrial cristae remodeling. bioRxiv : the preprint server for biology (2023)
Christiano R R Alves, Leillani L Ha, Rebecca A Yaworski, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv : the preprint server for biology (2023)
Joana Ferreira da Silva, Connor J Tou, Emily M King, Madeline L Eller, Linyuan Ma, David Rufino-Ramos, Benjamin P Kleinstiver
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. bioRxiv : the preprint server for biology (2023)
Zachariah L McLean, Dadi Gao, Kevin Correia, Jennie C L Roy, Shota Shibata, Iris N Farnum, Zoe Valdepenas-Mellor, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P Kleinstiver, Jong-Min Lee, Marcy E MacDonald, Vanessa C Wheeler, Ricardo Mouro Pinto, James F Gusella
PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington's disease. bioRxiv : the preprint server for biology (2023)
Michelle Y Fry, Paula P Navarro, Xingping Qin, Zintis Inde, Virly Y Ananda, Camila Makhlouta Lugo, Pusparanee Hakim, Bridget E Luce, Yifan Ge, Julie L McDonald, Ilzat Ali, Leillani L Ha, Benjamin P Kleinstiver, David C Chan, Kristopher A Sarosiek, Luke H Chao
In situ architecture of Opa1-dependent mitochondrial cristae remodeling. bioRxiv : the preprint server for biology (2023)
Christiano R R Alves, Leillani L Ha, Rebecca A Yaworski, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv : the preprint server for biology (2023)
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morín, Almudena Fernández, Logan T Hille, Rachel A Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A Gavira, Adrian Diaz, Wim F Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J M Mojica, Benjamin P Kleinstiver, Miguel Angel Moreno-Pelayo, Lluís Montoliu, Raul Perez-Jimenez
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins. Nature microbiology 8 (1) (2023)
Kathleen A Christie, Jimmy A Guo, Rachel A Silverstein, Roman M Doll, Megumu Mabuchi, Hannah E Stutzman, Jiecong Lin, Linyuan Ma, Russell T Walton, Luca Pinello, Gregory Brett Robb, Benjamin P Kleinstiver
Precise DNA cleavage using CRISPR-SpRYgests. Nature biotechnology (2022)
Connor J Tou, Benjamin P Kleinstiver
Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies. Biochemistry (2022)
Jeremy Vicencio, Carlos Sánchez-Bolaños, Ismael Moreno-Sánchez, David Brena, Charles E Vejnar, Dmytro Kukhtar, Miguel Ruiz-López, Mariona Cots-Ponjoan, Alejandro Rubio, Natalia Rodrigo Melero, Jesús Crespo-Cuadrado, Carlo Carolis, Antonio J Pérez-Pulido, Antonio J Giraldez, Benjamin P Kleinstiver, Julián Cerón, Miguel A Moreno-Mateos
Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes. Nature communications 13 (1) (2022)
Cholpisit Kiattisewee, Ava V Karanjia, Mateusz Legut, Zharko Daniloski, Samantha E Koplik, Joely Nelson, Benjamin P Kleinstiver, Neville E Sanjana, James M Carothers, Jesse G Zalatan
Expanding the Scope of Bacterial CRISPR Activation with PAM-Flexible dCas9 Variants. ACS synthetic biology (2022)
Logan T Hille, Benjamin P Kleinstiver
Plant genome editing branches out. Nature plants 7 (1) (2021)
Cameron S McAlpine, Joseph Park, Ana Griciuc, Eunhee Kim, Se Hoon Choi, Yoshiko Iwamoto, Máté G Kiss, Kathleen A Christie, Claudio Vinegoni, Wolfram C Poller, John E Mindur, Christopher T Chan, Shun He, Henrike Janssen, Lai Ping Wong, Jeffrey Downey, Sumnima Singh, Atsushi Anzai, Florian Kahles, Mehdi Jorfi, Paolo Fumene Feruglio, Ruslan I Sadreyev, Ralph Weissleder, Benjamin P Kleinstiver, Matthias Nahrendorf, Rudolph E Tanzi, Filip K Swirski
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature 595 (7869) (2021)
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Irene Scarfo, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Matthew J Frigault, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung, Marcela V Maus
Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources. Journal for immunotherapy of cancer 8 (2) (2021)
Russell T Walton, Jonathan Y Hsu, J Keith Joung, Benjamin P Kleinstiver
Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA. Nature protocols 16 (3) (2021)
Julie Brault, Taylor Q Liu, Ezekiel Ayo Bello, Siyuan Liu, Colin L Sweeney, Ronald J Meis, Sherry Koontz, Cristina Corsino, Uimook Choi, Guillaume Vayssière, Marita Bosticardo, Kennichi C Dowdell, Cicera R Lazzarotto, Aaron Clark, Luigi Daniele Notarangelo, Juan C Ravell, Michael J Lenardo, Benjamin P Kleinstiver, Shengdar Tsai, Xiaolin Wu, Gary A Dahl, Harry L Malech, Suk See De Ravin
CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes. Blood (2021)
Suk See De Ravin, Julie Brault, Ronald J Meis, Siyuan Liu, Linhong Li, Mara Pavel-Dinu, Cicera R Lazzarotto, Taylor Q Liu, Sherry M Koontz, Uimook Choi, Colin L Sweeney, Narda Theobald, GaHyun Lee, Aaron B Clark, Sandra Sczerba Burkett, Benjamin P Kleinstiver, Matthew H Porteus, Shengdar Tsai, Douglas B Kuhns, Gary A Dahl, Stephen J Headey, Xiaolin Wu, Harry L Malech
Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells. Blood 137 (19) (2021)
Russell T Walton, Kathleen A Christie, Madelynn N Whittaker, Benjamin P Kleinstiver
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants. Science (New York, N.Y.) 368 (6488) (2020)
Caroline Mahendra, Kathleen A Christie, Beatriz A Osuna, Rafael Pinilla-Redondo, Benjamin P Kleinstiver, Joseph Bondy-Denomy
Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer. Nature microbiology 5 (4) (2020)
Peter C DeWeirdt, Kendall R Sanson, Annabel K Sangree, Mudra Hegde, Ruth E Hanna, Marissa N Feeley, Audrey L Griffith, Teng Teng, Samantha M Borys, Christine Strand, J Keith Joung, Benjamin P Kleinstiver, Xuewen Pan, Alan Huang, John G Doench
Optimization of AsCas12a for combinatorial genetic screens in human cells. Nature biotechnology 39 (1) (2020)
Cort B Breuer, Killian S Hanlon, Jeya-Shree Natasan, Adrienn Volak, Amine Meliani, Federico Mingozzi, Benjamin P Kleinstiver, James J Moon, Casey A Maguire
In vivo engineering of lymphocytes after systemic exosome-associated AAV delivery. Scientific reports 10 (1) (2020)
Killian S Hanlon, Benjamin P Kleinstiver, Sara P Garcia, Mikołaj Piotr Zaborowski, Adrienn Volak, Stefan E Spirig, Alissa Muller, Alexander A Sousa, Shengdar Q Tsai, Niclas E Bengtsson, Camilla Lööv, Martin Ingelsson, Jeffrey S Chamberlain, David P Corey, Martin J Aryee, J Keith Joung, Xandra O Breakefield, Casey A Maguire, Bence György
High levels of AAV vector integration into CRISPR-induced DNA breaks. Nature communications 10 (1) (2019)
Bence György, Carl Nist-Lund, Bifeng Pan, Yukako Asai, K Domenica Karavitaki, Benjamin P Kleinstiver, Sara P Garcia, Mikołaj P Zaborowski, Paola Solanes, Sofia Spataro, Bernard L Schneider, J Keith Joung, Gwenaëlle S G Géléoc, Jeffrey R Holt, David P Corey
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nature medicine 25 (7) (2019)
Benjamin P Kleinstiver, Alexander A Sousa, Russell T Walton, Y Esther Tak, Jonathan Y Hsu, Kendell Clement, Moira M Welch, Joy E Horng, Jose Malagon-Lopez, Irene Scarfo, Marcela V Maus, Luca Pinello, Martin J Aryee, J Keith Joung
Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nature biotechnology 37 (3) (2019)
Nicole D Marino, Jenny Y Zhang, Adair L Borges, Alexander A Sousa, Lina M Leon, Benjamin J Rauch, Russell T Walton, Joel D Berry, J Keith Joung, Benjamin P Kleinstiver, Joseph Bondy-Denomy
Discovery of widespread type I and type V CRISPR-Cas inhibitors. Science (New York, N.Y.) 362 (6411) (2018)