Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
Slaven CrnkovicSonja RittchenKatharina JandlJuergen GindlhuberDiana ZabiniAyse Ceren MutganFrancesco ValzanoPanja M BoehmKonrad HoetzeneckerWolfgang TollerChristine VeithAkos HeinemannRalph T SchermulyAndrea OlschewskiLeigh Matthew MarshGrazyna KwapiszewskaPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
In sum, pulmonary vascular remodeling was dependent on ephrin-B2-induced Eph receptor (erythropoietin-producing hepatocellular carcinoma receptor) forward signaling in SMC, while EphB4 receptor activity was necessary for RhoA expression in SMC, interaction with endothelial cells and vasoconstrictive components of pulmonary hypertension.