Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.

Slaven Crnkovic Sonja RittchenKatharina JandlJuergen GindlhuberDiana ZabiniAyse Ceren MutganFrancesco ValzanoPanja M BoehmKonrad HoetzeneckerWolfgang TollerChristine VeithAkos HeinemannRalph T SchermulyAndrea OlschewskiLeigh Matthew Marsh Grazyna Kwapiszewska

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

In sum, pulmonary vascular remodeling was dependent on ephrin-B2-induced Eph receptor (erythropoietin-producing hepatocellular carcinoma receptor) forward signaling in SMC, while EphB4 receptor activity was necessary for RhoA expression in SMC, interaction with endothelial cells and vasoconstrictive components of pulmonary hypertension.

Keyphrases

pulmonary hypertension
endothelial cells
pulmonary artery
high glucose
pulmonary arterial hypertension
binding protein
poor prognosis
drug induced