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Nuclear Localization of BRAF V600E Is Associated with HMOX-1 Upregulation and Aggressive Behavior of Melanoma Cells.

Mourad ZerfaouiEman Ali ToraihEmmanuelle RuizYoussef ErramiAbdallah S AttiaMoroz KrzysztofZakaria Y Abd ElmageedEmad Kandil
Published in: Cancers (2022)
/HMOX-1/AKT axis plays an essential role in melanoma cell proliferation. Targeting HMOX-1 could be a novel method for treating melanoma patients who develop BRAF inhibitor resistance.
Keyphrases
  • cell proliferation
  • signaling pathway
  • metastatic colorectal cancer
  • cell cycle
  • skin cancer
  • pi k akt
  • wild type
  • poor prognosis
  • basal cell carcinoma
  • cancer therapy
  • drug delivery