Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study.
Mohammad U ZahidMatthew WaguespackRebecca C HarmanEric M KercherShubhankar NathTayyaba HasanImran RizviBryan Q SpringHeiko EnderlingPublished in: British journal of cancer (2024)
There is promise for applying fractionated PIT in the setting of EOC. However, recommending specific fractionated PIT dosimetry and timing will require appropriate model calibration on tumour-immune interaction data in human patients and subsequent validation of model predictions in prospective clinical trials.
Keyphrases
- immune response
- clinical trial
- end stage renal disease
- endothelial cells
- ejection fraction
- chronic kidney disease
- newly diagnosed
- big data
- prognostic factors
- randomized controlled trial
- machine learning
- small cell lung cancer
- dendritic cells
- toll like receptor
- patient reported outcomes
- study protocol
- inflammatory response
- patient reported
- deep learning
- phase ii