Neopterin Relates to Lifetime Depression in Older Adults With HIV on Suppressive Antiretroviral Therapy.
Rowan SalonerNatalie SaviniScott L LetendreDavid J MooreJessica L MontoyaPublished in: Journal of acquired immune deficiency syndromes (1999) (2022)
Neopterin was associated with lifetime MDD, but not current depressive symptoms in older PWH on suppressive ART. This may reflect a legacy of inflammation-related disruptions to amino acid metabolism and neurotransmitter synthesis, similar to prior observations. Identification of biopsychosocial and resilience factors underlying the null association between neopterin and current depression in older PWH is warranted.
Keyphrases
- antiretroviral therapy
- depressive symptoms
- hiv infected
- human immunodeficiency virus
- hiv positive
- community dwelling
- hiv aids
- social support
- middle aged
- hiv infected patients
- physical activity
- sleep quality
- amino acid
- oxidative stress
- major depressive disorder
- hepatitis c virus
- climate change
- men who have sex with men
- drug induced