Flavone Hispidulin Stimulates Glucagon-Like Peptide-1 Secretion and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice.

Yao WangAiping WangHana AlkhalidyJing LuoElizabeth MoomawAndrew P Neilson Dongmin Liu

Published in: Molecular nutrition & food research (2020)

These findings suggest that Hispidulin may be a novel dual-action anti-diabetic compound via stimulating GLP-1 secretion and suppressing hepatic glucose production.

Keyphrases

diabetic rats
oxidative stress
type diabetes
signaling pathway
high glucose
high fat diet
mouse model
blood glucose
wound healing
metabolic syndrome
drug induced
adipose tissue
endothelial cells
diabetic nephropathy
blood pressure