Photochemical Access to Substituted β-Lactams and β-Lactones via the Zimmerman-O'Connell-Griffin Rearrangement.

August Runemark Mario MartosMartin NigríniFrancoise M Amombo Noa Lars Öhrström Henrik Sundén

Published in: Organic letters (2023)

A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman-O'Connell-Griffin (ZOG) rearrangement in [2 + 2] cycloaddition. Products are obtained in high yield with excellent diastereoselectivity under visible light irradiation and under mild reaction conditions.

Keyphrases

visible light
molecular docking
randomized controlled trial
molecular dynamics simulations
radiation therapy
gold nanoparticles