Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series.

Didier PayenValerie FaivreJordi MiatelloJenneke LeentjensCaren BrumptPierre TissièresClaire DupuisPeter PickkersAnne Claire Lukaszewicz

Published in: BMC infectious diseases (2019)

Guided by clinical and immunological monitoring, adjunctive immunotherapy with IFNγ appears well-tolerated in our cases and improves immune host defense in sepsis induced immuno suppression. Randomized clinical studies to assess its potential clinical benefit are warranted.

Keyphrases

high glucose
diabetic rats
acute kidney injury
intensive care unit
dendritic cells
septic shock
immune response
open label
randomized controlled trial
double blind
stem cells
clinical trial
mesenchymal stem cells