Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection.
Yuanyang ChenXu LiZhi-Wei WangShun YuanXiaoyan ShenXiaoping XieKai XingQingyi ZhuPublished in: Molecular medicine (Cambridge, Mass.) (2024)
The survival period of ID mice was significantly shortened and the pathological staining results were the worst. Transcriptomic sequencing indicated that HIF1 was closely related to ID and the experimental results indicated that ID might regulate HIF1 expression by affecting oxygen balance. HIF1 activation regulates the phenotypic transformation of VSMC and participates in the occurrence and development of AD in vivo and in vitro.PX478, the inhibition of HIF1, can improve ID-induced AD exacerbation.
Keyphrases
- endothelial cells
- signaling pathway
- aortic dissection
- iron deficiency
- single cell
- high glucose
- poor prognosis
- chronic obstructive pulmonary disease
- risk assessment
- epithelial mesenchymal transition
- pi k akt
- intensive care unit
- adipose tissue
- binding protein
- drug induced
- rna seq
- metabolic syndrome
- induced apoptosis
- extracorporeal membrane oxygenation