Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial.
Antoine RoquillyBruno FrancoisOlivier HuetYoann LauneySigismond LasockiEmmanuel WeissMelanie PetrierYannick HourmantMarwan BourasKarim LakhalCecilia Le BelDelphine Flattres DuchaussoyLaia Fernández-BaratAdrian CeccatoLaurent FletAlexandra JobertJeremie PoschmannVeronique SebilleFanny FeuilletDespoina KoulentiAntoni Torresnull nullPublished in: Intensive care medicine (2023)
Among mechanically ventilated patients with acute organ failure, treatment with interferon gamma-1b compared with placebo did not significantly reduce the incidence of hospital-acquired pneumonia or death on day 28. Furthermore, the trial was discontinued early due to safety concerns about interferon gamma-1b treatment.