Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats.

Lorenz S NeuwirthGreg R PhillipsAbdeslem El Idrissi

Published in: Journal of biomedical science (2018)

Perinatal Pb2+ exposure disrupts the expression of mRNAs related to the GABA-shift, potentially altering the establishment, organization, and excitability of neural circuits across development. These findings offer new insights into the altered effects Pb2+ has on the GABAergic system preceding what is known regarding Pb2+ insults unto the glutamatergic system.

Keyphrases

heavy metals
poor prognosis
aqueous solution
pregnant women
risk assessment
binding protein
genome wide
gene expression
dna methylation
transcription factor
drug induced
congenital heart disease