Melatonin Supplementation for Six Weeks Had No Effect on Arterial Stiffness and Mitochondrial DNA in Women Aged 55 Years and Older with Insomnia: A Double-Blind Randomized Controlled Study.
Yonghwan KimHee Taik KangDuk-Chul LeePublished in: International journal of environmental research and public health (2021)
We found no evidence that melatonin supplementation improved cardiometabolic parameters like arterial stiffness, mtDNA, or insulin resistance compared to the placebo between baseline and week six. Sleep quality was improved in the melatonin group. Further research, including longer-term studies with higher doses of melatonin, is warranted.
Keyphrases
- mitochondrial dna
- sleep quality
- copy number
- insulin resistance
- double blind
- placebo controlled
- polycystic ovary syndrome
- blood pressure
- physical activity
- depressive symptoms
- phase iii
- open label
- adipose tissue
- type diabetes
- metabolic syndrome
- high fat diet
- gene expression
- randomized controlled trial
- clinical trial
- middle aged
- dna methylation
- pregnancy outcomes
- study protocol
- weight loss