Significance of Malignant Peritoneal Cytology on the Survival of Women with Early-Stage Cervical Cancer: A Japanese Gynecologic Oncology Group Study.
Koji MatsuoMuneaki ShimadaShinya MatsuzakiHiroko MachidaYoshikazu NagaseToshiaki SaitoShoji KamiuraTakashi IwataToru SugiyamaMikio MikamiPublished in: Journal of clinical medicine (2019)
This study examined the association between peritoneal cytology and survival in early-stage cervical cancer. This is a nationwide multicenter retrospective study, examining consecutive women with clinical stage IB1-IIB cervical cancer who underwent radical hysterectomy with available peritoneal cytology results from 2004-2008. Propensity score inverse probability of treatment weighting was used to assess the impact of malignant peritoneal cytology on survival. Among 1409 analyzed cases, 88 (6.2%) had malignant peritoneal cytology. On weighted models, malignant peritoneal cytology was associated with decreased disease-free survival (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.36-2.32) and overall survival (OS, HR 1.93, 95% CI 1.44-2.59). On sensitivity analyses, malignant peritoneal cytology was associated with decreased OS in adenocarcinoma/adenosquamous carcinoma, high-risk early-stage disease and those who received concurrent chemo-radiotherapy. However, among women who received postoperative systemic chemotherapy, malignant peritoneal cytology was not associated with OS (HR 1.21, 95% CI 0.72-2.04). A systematic review, including our results, showed that malignant peritoneal cytology was associated with decreased OS (HR 4.03, 95% CI 1.81-8.99) and increased recurrence in squamous carcinoma (odds ratio 1.89, 95% CI 1.05-3.39) and adenocarcinoma (odds ratio 4.30, 95% CI 2.30-8.02). In conclusion, the presence of malignant cells in peritoneal cytology is associated with decreased survival in early-stage cervical cancer. The possible benefit of systemic chemotherapy in this subgroup merits further investigation.
Keyphrases
- fine needle aspiration
- early stage
- high grade
- free survival
- ultrasound guided
- locally advanced
- low grade
- rectal cancer
- randomized controlled trial
- palliative care
- induced apoptosis
- magnetic resonance
- magnetic resonance imaging
- radiation therapy
- metabolic syndrome
- clinical trial
- adipose tissue
- oxidative stress
- neoadjuvant chemotherapy
- pregnant women
- photodynamic therapy
- open label
- radiation induced
- computed tomography
- phase iii