The association of BMI and sarcopenia with survival in patients with glioblastoma multiforme.
Deniz Can GuvenMelek Seren AksunIbrahim Yahya CakirSaadettin KilickapNeyran KertmenPublished in: Future oncology (London, England) (2021)
Background: The association between obesity and sarcopenia (via temporal muscle thickness) with overall survival (OS) has been evaluated in several glioblastoma multiforme studies, however, the data are inconclusive. Methods: The authors conducted meta-analyses via the generic inverse-variance method with a random-effects model. Results: In the pooled analysis of five studies, including 973 patients, patients with lower temporal muscle thickness had significantly decreased OS (HR: 1.62, 95% CI: 1.16-2.28, p = 0.005). The pooled analysis of five studies, including 2131 patients, demonstrated decreased OS in patients with lower BMI compared with patients with obesity (HR: 1.45, 95% CI: 1.12-1.88, p = 0.005). Conclusion: Readily available body composition parameters could be used for prognosis prediction and to aid in treatment decisions in patients with glioblastoma multiforme.
Keyphrases
- body composition
- end stage renal disease
- skeletal muscle
- newly diagnosed
- chronic kidney disease
- ejection fraction
- metabolic syndrome
- insulin resistance
- type diabetes
- weight gain
- systematic review
- peritoneal dialysis
- prognostic factors
- body mass index
- weight loss
- randomized controlled trial
- patient reported outcomes
- case control
- resistance training
- meta analyses
- clinical trial
- electronic health record
- study protocol
- artificial intelligence
- community dwelling
- replacement therapy
- smoking cessation