Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration.

Akihiro IkunoKoji AkedaShin-Ichiro TakebayashiMotomu ShimaokaKatsuzumi OkumuraAkihiro Sudo

Published in: PloS one (2019)

We conducted a genome-wide DNA methylation profile comparative study and observed significant differences in DNA methylation profiles between early and advanced stages of human IVD degeneration. These results implicate DNA methylation in the process of human IVD degeneration.

Keyphrases

dna methylation
genome wide
endothelial cells
gene expression
copy number
induced pluripotent stem cells
pluripotent stem cells