Immunogenicity evaluation of recombinant Lactobacillus casei W56 expressing bovine viral diarrhea virus E2 protein in conjunction with cholera toxin B subunit as an adjuvant.
Shuo JiaXinning HuangHua LiDianzhong ZhengLi WangXinyuan QiaoYanping JiangWen CuiLijie TangYijing LiYigang XuPublished in: Microbial cell factories (2020)
The genetically engineered Lactobacillus vaccine constructed in this study is immunogenic in mice and can induce mucosal, humoral, and cellular immune responses, providing effective anti-BVDV immune protection. It thus represents a promising strategy for vaccine development against BVDV.