Expression of the growth hormone receptor isoforms and its correlation with the metabolic profile in morbidly obese subjects.

Etual EspinosaLatife SalameDaniel Marrero-RodriguezAndy-Michel Romero-NievesDalia CuencaOsvaldo-Daniel Castelan-MartínezVictoria MendozaGustavo Ponce-NavarreteMauricio SalcedoEnrique Luque-LeònArturo Rodriguez-GonzalezMercado Moises

Published in: Endocrine (2018)

The heterozygous GHR +3/-3 genotype is more prevalent in subjects with morbid obesity. Patients expressing the exon +3 and exon -3 isoforms in adipose tissue had a higher HbA1c, than those expressing only the exon -3 isoform.

Keyphrases

adipose tissue
bariatric surgery
growth hormone
weight loss
end stage renal disease
insulin resistance
obese patients
metabolic syndrome
type diabetes
newly diagnosed
chronic kidney disease
poor prognosis
peritoneal dialysis
prognostic factors
high fat diet
early onset
binding protein
patient reported