Login / Signup

Performance of Amperometric Platinized-Nafion Based Gas Phase Sensor for Determining Nitric Oxide (NO) Levels in Exhaled Human Nasal Breath.

Joanna ZajdaNicholas J SchmidtZheng ZhengXuewei WangMark E Meyerhoff
Published in: Electroanalysis (2018)
Nitric oxide (NO) levels in exhaled breath are a non-invasive marker that can be used to diagnose various respiratory diseases and monitor a patient's response to given therapies. A portable and inexpensive device that can enable selective NO concentration measurements in exhaled breath samples is needed. Herein, the performance of an amperometric Pt-Nafion-based gas phase sensor for detection of NO in exhaled human nasal breath is examined. Enhanced selectivity over carbon monoxide and ammonia is achieved via an in-line zinc oxide-based filter. Exhaled nasal NO levels measured in 21 human samples with the sensor are shown to correlate well with those obtained using a chemiluminescence reference method (R2 = 0.9836).
Keyphrases
  • nitric oxide
  • endothelial cells
  • hydrogen peroxide
  • induced pluripotent stem cells
  • pluripotent stem cells
  • nitric oxide synthase
  • chronic rhinosinusitis
  • mass spectrometry
  • label free