Wnt/β-catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light-emitting diodes that regulate the proliferation of human outer root sheath cells.
Jung E KimYoung J WooKi M SohnKwan H JeongHoon KangPublished in: Lasers in surgery and medicine (2017)
These results demonstrate that LED light irradiation induced hORSC proliferation and migration and inhibited apoptosis in vitro. The growth-promoting effects of LEDs on hORSCs appear to be associated with direct stimulation of the Wnt5a/β-catenin and ERK signaling pathway. Lasers Surg. Med. 49:940-947, 2017. © 2017 Wiley Periodicals, Inc.
Keyphrases
- cell cycle arrest
- pi k akt
- cell proliferation
- signaling pathway
- induced apoptosis
- epithelial mesenchymal transition
- endothelial cells
- high glucose
- stem cells
- endoplasmic reticulum stress
- diabetic rats
- cell death
- oxidative stress
- induced pluripotent stem cells
- light emitting
- pluripotent stem cells
- bone marrow
- radiation therapy
- smoking cessation