Worldwide, alcohol causes a death every 10 s. The harmful effects are much wider in terms of impaired health and wellbeing of those affected and their families, particularly the most disadvantaged. The wider societal impact and financial costs are huge. Scotland, which has a particularly unhealthy relationship with alcohol and where the cost of alcohol harm is estimated at £3.6 billion, has introduced innovative public health measures such as minimum unit pricing (MUP). However, the Covid-19 pandemic has seen the death toll rising. This article examines the history of alcohol harm and policy interventions in Scotland in recent decades. The lessons learned provide a range of measures of proven efficacy that clinicians and government should employ to tackle Scotland's on-going alcohol crisis, and should be of interest to clinicians and policy makers everywhere.