Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians.

Lachlan CribbJenifer MurphyAmy Froud Georgina Oliver Chad A BousmanChee H NgJerome Sarris

Published in: Nutritional neuroscience (2017)

Precursor LC-PUFAs, LA and ALA, appear to be associated with MDD and potentially modulated by genetic variation in the FADS gene cluster. These results provide support for the consideration of PUFA composition, diet and FADS genetic variation in the pathophysiology of MDD.

Keyphrases

fatty acid
major depressive disorder
depressive symptoms
physical activity
weight loss
copy number
genome wide
bipolar disorder
simultaneous determination
genome wide identification
high resolution
tandem mass spectrometry