Prevention of Postoperative Events following Reversal with Sugammadex or Neostigmine (the P-PERSoN Trial): Pilot Data Following Early Termination of a Prospective, Blinded, Randomised Trial.

Benjamin L Olesnicky Matthew A DoaneClare FarrellGreg KnoblancheAnthony Delaney

Published in: Anesthesiology research and practice (2022)

The P-PERSoN trial showed no difference in postoperative pulmonary complications between sugammadex and neostigmine based reversal of aminosteroid neuromuscular block, but was underpowered to show any difference due to early trial termination. The randomisation and data collection was feasible. We support the need for an adequately resourced and funded randomised controlled trial to address this important clinical question.

Keyphrases

study protocol
randomized controlled trial
phase iii
clinical trial
open label
phase ii
patients undergoing
electronic health record
big data
pulmonary hypertension
placebo controlled
risk factors
artificial intelligence