AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells.
Sofia Mônaco GamaVanessa Araújo VarelaNatalia Mazini RibeiroBruna BizzarroCamila HernandesThiago Pinheiro Arrais AloiaMariane Tami AmanoWelbert Oliveira PereiraPublished in: Einstein (Sao Paulo, Brazil) (2023)
The AKT pathway is involved in resistance to natural Killer-induced apoptosis in HL60 cells by regulating the expression of immune suppressor receptors. These findings highlight the importance of AKT in contributing to immune evasion mechanisms in acute myeloid leukemia and suggests the potential of AKT inhibition as an adjunct to immunotherapy.