Sesquiterpenoids from Seriphidium transiliense and Their Melanogenic Activity.
Jun-Fang WuAblajan TurakDeng ZangGuo-An ZouHaji Akber AisaPublished in: Journal of natural products (2022)
A sesquiterpenoid with an unprecedented 5/5/4 tricyclic skeleton ( 1 ), a nor -sesquiterpenoid with a rare 6/7 bicyclic skeleton ( 2 ), 10 new sesquiterpenoids ( 3 - 12 ), and six known analogues ( 13 - 18 ) were isolated from the whole plants of Seriphidium transiliense . The structures of compounds 1 - 12 were elucidated by spectroscopic data analysis. Compound 7 showed melanogenic promotion activity in murine melanoma (B16) cells more potent than the positive control used, 8-methoxypsoralen (8-MOP). Further mechanistic studies indicated that compound 7 promotes melanogenesis through activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes in B16 cells. Moreover, compound 7 also inhibited the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells. These results suggest that the sesquiterpenoid 7 shows potential activity for treating vitiligo.
Keyphrases
- signaling pathway
- transcription factor
- data analysis
- induced apoptosis
- endothelial cells
- molecular docking
- poor prognosis
- epithelial mesenchymal transition
- genome wide
- dendritic cells
- risk assessment
- cell cycle arrest
- climate change
- long non coding rna
- cell death
- mass spectrometry
- dna binding
- induced pluripotent stem cells
- genome wide identification
- structure activity relationship
- basal cell carcinoma