PathSTORM: a road to early cancer detection.
Kris TroyYang LiuSarah J HainerPublished in: Molecular & cellular oncology (2020)
Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.
Keyphrases
- label free
- dna damage
- gene expression
- single molecule
- high resolution
- loop mediated isothermal amplification
- transcription factor
- high speed
- genome wide
- real time pcr
- papillary thyroid
- multiple sclerosis
- high throughput
- copy number
- optical coherence tomography
- dna methylation
- squamous cell carcinoma
- risk assessment
- mass spectrometry
- lymph node metastasis
- young adults
- sensitive detection