Optimizing of a suitable protocol for isolating tissue-derived extracellular vesicles and profiling small RNA patterns in hepatocellular carcinoma.

Wenjing YangYu LiuJiyan WangTe LiuTongtong TianTong LiLin DingWei ChenHao WangJie ZhuChunyan ZhangBaishen PanJian ZhouJia FanBeili WangXin-Rong Yang Wei Guo

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

The NC protocol was optimal for isolating EVs from HCC, especially from frozen tissues. Our study emphasized the different roles of small-RNA in regulating the HCC ecosystem, providing insights into HCC progression and potential therapeutic targets.

Keyphrases

randomized controlled trial
human health
climate change
gene expression
single cell
risk assessment