Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.

Jonathan J HernandezDoyle E BeatyLogan L FruhwirthAna P Lopes ChavesNeil H Riordan

Published in: Journal of translational medicine (2021)

We have demonstrated negative expression of ACE2 and low expression of TMPRSS2 in 24 lots of hUC-MSCs. This has crucial implications for the design of future therapeutic options for COVID-19, since hUC-MSCs would have the ability to "dodge" viral infection to exert their immunomodulatory effects.

Keyphrases

umbilical cord
mesenchymal stem cells
poor prognosis
coronavirus disease
endothelial cells
binding protein
sars cov
angiotensin ii
bone marrow