The Role of GDF15 in Regulating the Canonical Pathways of the Tumor Microenvironment in Wild-Type p53 Ovarian Tumor and Its Response to Chemotherapy.

Daisy I IzaguirreChun-Wai NgSuet-Yan KwanEucharist H KunYvonne T M TsangDavid M GershensonKwong-Kwok Wong

Published in: Cancers (2020)

GDF15 expression from the wild-type p53 cancer cells can modulate the canonical pathways in the tumor microenvironment in response to cisplatin, which is a possible mechanism of chemoresistance.

Keyphrases

wild type
poor prognosis
locally advanced
binding protein
squamous cell carcinoma
long non coding rna
radiation therapy
rectal cancer
cancer stem cells