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miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy.

Qian HuangJiajia XiaLei WangXu WangXiaodong MaQipan DengYong LuMunish KumarZhiyuan ZhouLing LiZhaoyang ZengKen H YoungQing YiMingzhi ZhangYong Li
Published in: Journal of hematology & oncology (2018)
These findings indicate that miR-153 inhibits IDO1 expression in colon cancer cells and is a tumor-suppressive miRNA that enhances CAR T cell immunotherapy. This study supports the combinatorial use of IDO1 inhibitors and CAR T cells in treating solid tumors.
Keyphrases
  • poor prognosis
  • long non coding rna
  • cell proliferation
  • long noncoding rna
  • signaling pathway