miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy.
Qian HuangJiajia XiaLei WangXu WangXiaodong MaQipan DengYong LuMunish KumarZhiyuan ZhouLing LiZhaoyang ZengKen H YoungQing YiMingzhi ZhangYong LiPublished in: Journal of hematology & oncology (2018)
These findings indicate that miR-153 inhibits IDO1 expression in colon cancer cells and is a tumor-suppressive miRNA that enhances CAR T cell immunotherapy. This study supports the combinatorial use of IDO1 inhibitors and CAR T cells in treating solid tumors.