PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study.

Alessandra Vecchiè Aldo BonaventuraJ MeessenD NovelliS MinettiE EliaD FerraraA M AnsaldoV ScaravilliS VillaL FerlaPietro Caironi Roberto Latini Federico Carbone Fabrizio Montecucconull null

Published in: Journal of internal medicine (2020)

In our sub-analysis of the ALBIOS trial, we found that patients with septic shock presenting with lower plasma PCSK9 levels experienced higher mortality rate. Further studies are warranted to better evaluate the pathophysiological role of PCSK9 in sepsis.

Keyphrases

septic shock
cardiovascular events
low density lipoprotein
risk factors
clinical trial
study protocol
electronic health record
phase iii
randomized controlled trial
phase ii
coronary artery disease
big data
case report
case control
open label