Chronic airway inflammation provides a unique environment for B cell activation and antibody production.

S FeldmanR KasjanskiJ PoposkiD HernandezJ N ChenJ E NortonL SuhR G CarterW W StevensA T PetersR C KernD B ConleyB K TanS Shintani-SmithK C WelchL C GrammerK E HarrisAtsushi KatoR P SchleimerK E Hulse

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)

Our data suggest there is a unique B cell activation environment within NP that is distinct from classic GC-mediated mechanisms. We show for the first time that ILC2s directly induce EBI2 expression on B cells, indicating that ILC2s may play an important role in B cell responses. B cell-targeted therapies may provide new treatment options for CRSwNP.

Keyphrases

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long non coding rna
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simultaneous determination